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KMID : 1202020080010020123
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Journal of Korean Thyroid Association
2008 Volume.1 No. 2 p.123 ~ p.128
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Diagnostic Utility of Galectin-3 in the US-guided Fine Needle Aspiration Cytology of Thyroid Nodules
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Kim Hyun-Sook
Cho Chang-Ho
Jung Eui-Dal
Yoon Hyun-Dae
Bae Jong-Yup
Shon Ho-Sang
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Abstract
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Background and Objectives: Fine needle aspiration biopsy (FNAB) is considered as the most feasible preoperative diagnostic tool for thyroid lesions. However, indeterminate results of FNAB are common, so many methods were developed as supportive preoperative diagnostic modalities in indeterminate results of FNAB. In our previous studies, galectin-3 was expressed preferentially in thyroid malignancies of postoperative tissue specimen. In the present study, we evaluated whether galectin-3 immunohistochemistry (IHC) is useful as a preoperative diagnostic tool in thyroid nodules.
Materials and Methods: A total of 151 thyroid nodules were performed US-guided FNAC and obtained from patients who underwent thyroidectomy were evaluated using papanicolaou-stained slides and cell blocks with galectin-3 IHC. IHC for Galectin-3 was performed. Cytologic diagnoses were correlated with the results of galectin-3 and categorized into 3 groups (benign, indeterminate, malignancy) and compared with the corresponding histologic diagnoses.
Results: Of 151 specimens, 113 (74.8%) were malignant. When the histologic diagnoses were compared with the galectin-3 IHC, there were 14 (9.2%) discrepant cases. In the result of US-guided FNAB, sensitivity, specificity, positive-predictive value, and negative predictive value of galectin-3 IHC were 90.2, 92.1, 97.1, 76.1%. In the indeterminate result of US-guided FNAB, sensitivity, specificity, positive-predictive value, and negative predictive value of galectin-3 were 50, 91.4, 60, 96.9%.
Conclusion: Galectin-3 IHC is a supplementary marker for the preoperative diagnoses of thyroid nodules in the US-guided FNAB. In the indeterminate of FNAB, galectin-3 IHC is not a reliable method for diagnosis, but negative staining of galectin-3 may raise the possibility of benign thyroid nodules.
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KEYWORD
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Thyroid Nodules, Fine Needle Aspiration biopsy, Galectin-3
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